Methandrostenolone, commonly known by its brand name Dianabol (D-Bol), is a synthetic anabolic steroid that has been widely used in the bodybuilding community for its potent muscle-building properties. As a derivative of testosterone, it exhibits significant anabolic effects, making it effective for rapid muscle mass development and strength enhancement.
This oral steroid is known for its ability to promote substantial muscle gains within a relatively short period, which has contributed to its popularity among athletes and bodybuilders. However, its use is also associated with various health risks and side effects that need to be carefully considered.
We will examine the pharmacological properties of methandrostenolone, its physiological mechanisms, and the potential benefits and risks associated with its use in athletic performance enhancement.
Key Takeaways
- Methandrostenolone is a potent anabolic steroid used for muscle building and strength enhancement.
- It is known for its oral bioavailability and rapid muscle mass development.
- The compound is associated with various health risks and side effects.
- Its use in bodybuilding is widespread despite the potential risks.
- Understanding its pharmacological properties is crucial for assessing its benefits and risks.
What is Methandrostenolone?
As a derivative of testosterone, methandrostenolone is classified as an anabolic steroid, widely used for its ability to promote muscle growth and enhance athletic performance. This compound has garnered significant attention in both medical and bodybuilding communities due to its potent effects.
Chemical Structure and Classification
Methandrostenolone, known scientifically as metandienone or methandienone, is characterized by its specific chemical structure, which is designed to enhance its anabolic properties while minimizing its androgenic effects. It is classified under the category of 17α-alkylated anabolic steroids, a modification that allows it to survive first-pass metabolism when taken orally, making it effective in oral form.
Common Names and Forms
Methandrostenolone is recognized by multiple nomenclature designations within pharmaceutical literature. Its International Nonproprietary Name (INN) is metandienone, while its British Approved Name (BAN) is methandienone. It was introduced and formerly sold primarily under the brand name Dianabol. Other brand names include Anabol, Danabol, Metanabol, and Naposim, among others. Pharmaceutical preparations of methandrostenolone were historically available in oral tablet form, with standard dosages ranging from 2.5mg to 10mg. Despite its discontinued status in many countries, methandrostenolone remains widely used in underground markets, particularly among bodybuilders seeking rapid muscle and strength gains.
Understanding methandrostenolone involves recognizing its role as a drug that has been utilized both therapeutically and for performance enhancement. Its history and development are closely tied to its effects on the body, which are characteristic of anabolic steroids.
The History and Development of Dianabol
Methandrostenolone, commonly referred to as Dianabol, was first synthesized in the 1950s by CIBA Pharmaceuticals. This potent anabolic steroid was initially developed for therapeutic purposes, including the treatment of hypogonadism and other conditions requiring muscle enhancement.
Origins in the 1950s
The development of Dianabol was a significant milestone in the history of performance enhancement. After its synthesis, the drug underwent various clinical trials to assess its efficacy and safety. By 1962, the Kefauver Harris Amendment had been passed, prompting the U.S. FDA to initiate the DESI review process to ensure that drugs approved under pre-1962 standards were safe and effective. Dianabol was among the drugs reviewed, and in 1965, CIBA was required to further document its legitimate medical uses, leading to its re-approval for specific therapeutic indications.
Evolution in Bodybuilding Culture
Dianabol’s introduction into bodybuilding culture marked a paradigm shift in the sport, significantly enhancing muscle mass and strength. The compound’s oral administration and relatively low cost made it accessible to both amateur and professional bodybuilders, contributing to its widespread adoption. Key aspects of its evolution include:
- The rapid gains in muscle mass and strength associated with Dianabol use.
- The compound’s influence on the “Golden Era” of bodybuilding in the 1960s and 1970s.
- The impact of regulatory scrutiny on its use, particularly following the FDA’s DESI review.
- The establishment of Dianabol as a prototypical “bulking” agent in steroid nomenclature.
The development and use of Dianabol in bodybuilding paralleled increasing regulatory oversight, yet its off-label use for performance enhancement continued to proliferate.
How Methandrostenolone Works in the Body
Methandrostenolone, a potent anabolic steroid, exerts its effects on the body through a complex interplay of biochemical processes. Understanding these mechanisms is crucial for appreciating its role in muscle growth and enhancement.
Interaction with Androgen Receptors
Methandrostenolone interacts with androgen receptors in muscle cells, triggering a cascade of intracellular signaling events that ultimately lead to increased protein synthesis and muscle growth. This interaction is fundamental to its anabolic effects, as it allows methandrostenolone to influence gene expression and promote the synthesis of new proteins.
Protein Synthesis Enhancement
One of the primary mechanisms through which methandrostenolone exerts its anabolic effects is by enhancing protein synthesis. By increasing the rate at which muscle cells synthesize new proteins, methandrostenolone supports muscle tissue growth and repair. This enhancement is critical for athletes seeking to improve muscle mass and strength.
Nitrogen Retention and Muscle Growth
Methandrostenolone promotes nitrogen retention, a critical factor in muscle anabolism. By maintaining a positive nitrogen balance, methandrostenolone creates an optimal environment for muscle protein accretion, leading to significant muscle growth. The table below summarizes the key effects of methandrostenolone on nitrogen retention and muscle growth.
Mechanism | Effect | Outcome |
Increased amino acid uptake | Enhanced nitrogen retention | Positive nitrogen balance |
Reduced amino acid oxidation | Increased protein synthesis | Muscle growth |
Enhanced renal reabsorption | Improved nitrogen utilization | Muscle hypertrophy |
The efficacy of methandrostenolone in enhancing nitrogen retention and promoting muscle growth is well-documented. By understanding its mechanisms of action, users can better appreciate its potential benefits and risks.
Pharmacological Properties of Methandrostenolone
Understanding methandrostenolone’s pharmacological characteristics is essential for assessing its efficacy and safety. Methandrostenolone, a synthetic anabolic steroid, interacts with the body in complex ways, influencing its anabolic and androgenic effects.
Bioavailability and Metabolism
Methandrostenolone undergoes extensive hepatic biotransformation through multiple enzymatic pathways, producing several metabolites unique to this compound. This metabolic process is crucial for its detoxification and elimination from the body. The liver plays a significant role in methandrostenolone’s metabolism, highlighting the potential for liver toxicity with its use.
- The compound is subject to significant first-pass metabolism, affecting its bioavailability.
- Metandienone is metabolized into various metabolites, some of which have been identified as unique markers for its detection.
Half-Life and Detection Time
The elimination half-life of methandrostenolone is relatively short, ranging from 3 to 6 hours, necessitating multiple daily doses to maintain its anabolic effects. Despite its short plasma half-life, methandrostenolone’s metabolites can be detected in urine for extended periods.
- Primary urinary metabolites are detectable for up to 3 days.
- A novel hydroxymethyl metabolite has been identified, which can remain detectable in urine for up to 19 days after a single 5mg dose.
Advanced analytical techniques, including gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-tandem mass spectrometry (LC-MS/MS), are used to detect methandrostenolone metabolites in urine samples, highlighting the challenges in detecting this drug in anti-doping tests.
Benefits of Methandrostenolone in Bodybuilding
In the realm of bodybuilding, Methandrostenolone is valued for its capacity to improve physical performance and accelerate muscle growth. This anabolic steroid has been widely used by athletes seeking to enhance their physique and gain a competitive edge.
Rapid Muscle Mass Gains
Methandrostenolone facilitates rapid gains in muscle mass due to its potent anabolic effects on the body. By enhancing protein synthesis and nitrogen retention, it creates an environment conducive to muscle growth. Athletes using Methandrostenolone often report significant increases in muscle mass within a short period.
The compound’s ability to improve glycogenolysis results in increased glucose availability for muscles, further contributing to enhanced endurance and muscle growth. This makes Methandrostenolone particularly beneficial for athletes engaged in high-intensity training.
Strength Enhancement
One of the primary reasons athletes turn to Methandrostenolone is its ability to significantly enhance strength. By interacting with androgen receptors, Methandrostenolone boosts the body’s natural strength capabilities, allowing athletes to lift heavier weights and perform at higher intensities.
Moreover, Methandrostenolone’s anti-catabolic properties help reduce muscle protein breakdown, thereby preserving muscle mass and contributing to overall strength gains. This dual action makes it an effective agent for athletes seeking to improve their power and performance.
Performance Improvements
Methandrostenolone’s impact on performance extends beyond mere muscle gain and strength enhancement. It also improves recovery times, allowing athletes to train more frequently and with greater intensity. The compound’s effects on erythropoiesis and oxygen-carrying capacity further enhance endurance, enabling athletes to sustain high-intensity efforts over longer periods.
Benefit | Description |
Rapid Muscle Mass Gains | Enhanced protein synthesis and nitrogen retention |
Strength Enhancement | Interaction with androgen receptors, boosting natural strength |
Performance Improvements | Improved recovery, erythropoiesis, and oxygen-carrying capacity |
Methandrostenolone Dosage Guidelines
Methandrostenolone dosage guidelines are crucial for bodybuilders seeking to maximize gains while minimizing risks. The potency of methandrostenolone, a powerful anabolic steroid, necessitates careful consideration of dosage to balance efficacy with potential side effects on the body, particularly the liver.
Beginner, Intermediate, and Advanced Protocols
Dosage protocols for methandrostenolone vary based on the user’s experience level. Beginners typically start with lower doses (15-20 mg/day) to assess tolerance, while intermediate users may increase the dosage (30-40 mg/day) to enhance muscle growth. Advanced users often push the dosage higher (50 mg/day or more), although this increases the risk of adverse effects, including strain on the liver. It’s essential to note that higher doses do not necessarily translate to greater gains and may significantly elevate the risk of complications.
Cycling Strategies
Cycling strategies for methandrostenolone are designed to maximize its anabolic effects while mitigating potential risks. Common strategies include limited duration protocols of 4-6 weeks to balance benefits against side effects. “Kickstart” cycles utilize methandrostenolone during the initial weeks of a longer steroid cycle to provide immediate results. Pyramid cycling protocols, though controversial, involve gradually increasing and then decreasing dosages. Post-cycle therapy is crucial for restoring natural testosterone production after methandrostenolone administration.
Stacking Methandrostenolone with Other Compounds
Combining methandrostenolone with other compounds requires careful consideration of the potential synergistic effects and risks. Stacking methandrostenolone with other anabolic steroids is a practice used by some bodybuilders to enhance muscle growth and performance. However, stacking increases the complexity and risk of side effects. Always research thoroughly and start with single-compound cycles if you’re a beginner.
Popular Stacking Combinations
Several stacking combinations have gained popularity among bodybuilders. Methandrostenolone/testosterone stacks are particularly common, as they combine the anabolic effects of methandrostenolone with the physiological hormone replacement provided by testosterone. Other combinations may include stacking methandrostenolone with compounds like trenbolone or stanozolol to achieve varied effects on muscle growth and strength.
Synergistic Effects
The synergistic effects observed in methandrostenolone stacking protocols can extend beyond simple additive benefits. Certain combinations demonstrate multiplicative effects through complementary mechanisms of action. For instance, combining short-acting compounds like methandrostenolone with longer-acting esters like testosterone enanthate creates more stable anabolic environments. Research indicates that carefully designed stacking protocols may allow for reduced dosages of individual components while maintaining equivalent anabolic effects, potentially providing a more favorable risk-benefit profile.
It’s crucial to consider the synergistic risk profiles when designing stacking protocols, as combinations may produce compounded adverse effects on hepatic, cardiovascular, and endocrine systems. The pharmacokinetic diversity achieved through strategic stacking can help mitigate some risks but requires careful planning and monitoring.
Common Side Effects of Methandrostenolone
As a potent anabolic steroid, Methandrostenolone’s side effect profile is significant and warrants careful consideration. The use of Methandrostenolone can lead to a variety of adverse effects, affecting different aspects of a user’s health.
Androgenic Side Effects
Methandrostenolone’s androgenic properties can cause several side effects, including acne, male pattern baldness, and increased body hair growth. These effects are due to the steroid’s ability to bind to androgen receptors, influencing various physiological processes. The severity of these side effects can vary among individuals, depending on genetic predispositions and dosage levels.
Estrogenic Side Effects
Estrogenic side effects associated with Methandrostenolone use include gynecomastia, water retention, and fat redistribution. These effects result from the steroid’s conversion to estrogen through aromatization. Managing estrogen levels through the use of aromatase inhibitors can help mitigate these side effects, although this approach also carries its own risks and considerations.
Psychological Effects
The psychological effects of Methandrostenolone can be profound, with users potentially experiencing mood swings, aggression, and other emotional changes. These effects are linked to the steroid’s impact on neurotransmitter balance, particularly serotonin and dopamine, which play crucial roles in regulating mood and emotional states. The phenomenon known as “roid rage” is a recognized, though not fully understood, consequence of Methandrostenolone use, characterized by increased irritability and hostility.
Furthermore, the discontinuation of Methandrostenolone can lead to post-cycle psychological disturbances, including depression and anxiety, as the body’s natural hormonal balance is restored. The variability in individual responses to Methandrostenolone underscores the importance of careful monitoring and management of its psychological effects.
Serious Health Risks Associated with Dianabol Use
Methandrostenolone use is linked to several severe health risks, affecting various bodily systems. The administration of this anabolic steroid can lead to significant complications, making it crucial for users to be aware of these potential dangers.
Liver Toxicity and Damage
Methandrostenolone is known to be hepatotoxic, meaning it can cause liver damage. This is because it is a C17-alpha-alkylated compound, which allows it to survive first-pass liver metabolism when taken orally. However, this modification can lead to liver strain and potentially severe liver damage. Prolonged use or high doses can exacerbate this risk, leading to conditions such as peliosis hepatis, where blood-filled cysts form in the liver.
Cardiovascular Complications
The use of Methandrostenolone can also lead to cardiovascular complications. It can cause changes in lipid profiles, leading to decreased high-density lipoprotein (HDL) cholesterol and increased low-density lipoprotein (LDL) cholesterol. This can result in atherosclerosis, increasing the risk of heart attacks, strokes, and other cardiovascular events. Furthermore, Methandrostenolone can cause hypertension, further straining the cardiovascular system.
Hormonal Imbalances
As an exogenous hormone, Methandrostenolone can disrupt the body’s natural hormone production. Prolonged use can suppress endogenous testosterone production, leading to hormonal imbalances, testicular atrophy, and potential infertility. The suppression of the hypothalamic-pituitary-gonadal axis can result in significantly reduced testosterone production, which may persist for months after discontinuation. Additionally, estrogen-related side effects can occur due to aromatization, leading to further changes in the body.
- Methandrostenolone administration produces profound suppression of the hypothalamic-pituitary-gonadal axis, resulting in significantly reduced endogenous testosterone production.
- Testicular atrophy and fertility impairment are significant concerns, with potential long-term effects on reproductive health.
- The hormonal disruptions extend beyond testosterone, potentially affecting thyroid function and insulin sensitivity.
Managing and Minimizing Side Effects
Effective management of methandrostenolone side effects requires a comprehensive approach that incorporates both preventive measures and timely interventions. This involves a combination of supportive supplements, medications, and rigorous health monitoring protocols to mitigate the risks associated with its use.
Supportive Supplements and Medications
The use of certain supplements and medications can help alleviate some of the side effects associated with methandrostenolone. For instance, liver support supplements such as milk thistle or N-acetyl cysteine may help protect the liver from damage. Additionally, medications like anti-estrogens can be used to counteract estrogenic side effects.
Health Monitoring Protocols
Regular health monitoring is crucial for early detection of potential side effects. This includes tracking liver enzymes (AST/ALT), lipid profiles (HDL/LDL), blood pressure, and monitoring for mood changes. Comprehensive pre-cycle, mid-cycle, and post-cycle laboratory assessments are essential for responsible methandrostenolone use.
- Comprehensive pre-cycle laboratory assessments include complete blood count, comprehensive metabolic panel, lipid profile, hormone panel, and cardiac biomarkers.
- Mid-cycle monitoring protocols should be implemented at 2-3 week intervals, focusing on hepatic enzymes, lipid profiles, and blood pressure measurements.
- Cardiovascular assessment should include regular blood pressure monitoring, with values consistently exceeding 140/90 mmHg warranting dosage reduction or discontinuation.
- Post-cycle laboratory evaluation should be conducted 4-6 weeks after discontinuation to assess recovery of hepatic function, lipid profiles, and endogenous hormone production.
By implementing these strategies, individuals can better manage the risks associated with methandrostenolone use and minimize its adverse effects on the body and overall health, particularly concerning cardiovascular health and reducing the risk of severe side effects.
Post Cycle Therapy After Methandrostenolone Use
The cessation of Methandrostenolone use can lead to a drastic decline in natural testosterone production, necessitating a comprehensive Post Cycle Therapy (PCT) protocol. PCT is designed to restore the body’s natural hormonal balance, mitigate the effects of steroid withdrawal, and support overall recovery.
Restoring Natural Hormone Production
Restoring natural hormone production after a Methandrostenolone cycle involves the use of specific compounds that stimulate the hypothalamic-pituitary-gonadal axis. This process is crucial for re-establishing the body’s natural testosterone production and minimizing the risk of long-term hormonal imbalances.
Recommended PCT Compounds
Several compounds are recommended for PCT after Methandrostenolone use, including:
- Tamoxifen citrate (Nolvadex), a selective estrogen receptor modulator, typically administered at 40mg daily for 2 weeks, followed by 20mg daily for 2 weeks.
- Clomiphene citrate (Clomid), another selective estrogen receptor modulator, given at 100mg daily for 2 weeks followed by 50mg daily for 2 weeks.
- Human chorionic gonadotropin (hCG), which mimics luteinizing hormone activity and directly stimulates testicular Leydig cells, usually implemented at 500-1000 IU every other day for 2 weeks.
- Enclomiphene, an emerging PCT option with potentially improved side effect profiles, though its availability is limited.
- Adjunctive compounds like D-aspartic acid, vitamin D, zinc, and magnesium may provide additional support for testosterone production and overall hormonal recovery.
By incorporating these compounds into a structured PCT protocol, individuals can effectively mitigate the adverse effects of Methandrostenolone cessation and support their body’s natural recovery processes.
Legal Status of Methandrostenolone Worldwide
The legal framework surrounding methandrostenolone use varies substantially from one country to another. This variability reflects different regulatory approaches and legal classifications of the substance.
United States Regulations
In the United States, methandrostenolone is classified as a Schedule III controlled substance under the Controlled Substances Act. This classification indicates that while it has accepted medical uses, it also has potential for abuse and dependence. Possession without a valid prescription is illegal and can result in significant penalties.
International Legal Framework
Globally, the legal status of methandrostenolone is diverse. Countries like Canada, the United Kingdom, and Australia have laws similar to those in the United States, classifying it as a controlled substance. In contrast, countries such as Mexico and Thailand have more lenient regulations, allowing it to be purchased over the counter. However, legality does not necessarily imply safety.
Country | Legal Status of Methandrostenolone |
United States | Schedule III controlled substance |
Canada | Schedule IV controlled substance |
United Kingdom | Class C controlled substance |
Mexico | Available over the counter |
Thailand | Minimally restricted access |
The World Anti-Doping Agency’s international convention against doping in sport prohibits methandrostenolone in competitive athletics, creating a standardized global framework for testing and sanctions despite variations in national legal status.
Methandrostenolone vs. Other Anabolic Steroids
Comparing methandrostenolone to other anabolic steroids reveals its effectiveness and potential side effects in a broader context. Methandrostenolone, known for its potent anabolic effects, is often used for bulking and strength gains. However, its benefits and drawbacks can be fully appreciated only when compared to other steroids.
Injectable Steroids Comparison
Methandrostenolone is an oral steroid, distinguishing it from injectable steroids like testosterone esters and nandrolone. Injectable steroids often have longer half-lives and may be less hepatotoxic. However, they require injections, which can be a drawback for some users.
Characteristics | Methandrostenolone | Testosterone Enanthate | Nandrolone Decanoate |
Administration Route | Oral | Injectable | Injectable |
Liver Toxicity | High | Low | Low |
Anabolic Potency | High | High | Moderate |
Estrogenic Activity | Moderate | High | Low |
Oral Compounds Comparison
When compared to other oral anabolic steroids like oxandrolone (Anavar) and stanozolol (Winstrol), methandrostenolone exhibits a higher anabolic potency, leading to more significant muscle mass and strength gains. However, this comes with a higher risk of side effects, including increased liver toxicity and estrogenic effects.
Characteristics | Methandrostenolone | Oxandrolone (Anavar) | Stanozolol (Winstrol) |
Anabolic Potency | High | Moderate | Moderate |
Liver Toxicity | High | Moderate | Moderate |
Estrogenic Activity | Moderate | Low | Low |
Water Retention | High | Low | Low |
Real-World Results and Expectations
When assessing the impact of Methandrostenolone, it’s essential to consider both the typical gains reported by users and the factors that influence individual response. Methandrostenolone is known for its potent anabolic effects on the body, contributing to significant muscle mass and strength growth.
Typical Gains from Methandrostenolone Cycles
Users of Methandrostenolone often report substantial gains in muscle mass and strength, particularly during the initial cycles. Typical gains range from 10-20 pounds of lean body mass within a 4-6 week cycle. These gains are largely attributed to the steroid’s ability to enhance protein synthesis and promote nitrogen retention in the muscles, leading to significant changes in body composition.
The anabolic effects of Methandrostenolone are dose-dependent, with higher doses typically resulting in more pronounced gains. However, increased dosage also elevates the risk of adverse effects, necessitating a careful balance between efficacy and safety.
Factors Affecting Individual Response
Several factors contribute to the variability in individual response to Methandrostenolone. Genetic factors play a significant role, with variations in androgen receptor density and metabolic pathways influencing both the efficacy and the side effect profile of the steroid.
- Genetic predispositions affecting androgen receptor density and metabolic efficiency
- Training experience and methodology, with more advanced trainees typically showing diminished relative gains
- Nutritional factors, particularly caloric intake and protein consumption, which optimize anabolic potential when managed correctly
- Age-related factors, with younger individuals demonstrating enhanced anabolic sensitivity but potentially greater susceptibility to adverse effects
- Concurrent medication use, which can alter the steroid’s effects and side effect profile through pharmacokinetic and pharmacodynamic interactions
Understanding these factors is crucial for maximizing the benefits of Methandrostenolone while minimizing its risk.
Is Methandrostenolone Worth the Risks?
Evaluating the worth of Methandrostenolone involves examining the delicate balance between its performance-enhancing effects and health risks. Despite its potential benefits in enhancing muscle mass and strength, the misuse and abuse of Methandrostenolone have raised concerns about its adverse effects on health, including side effects such as liver toxicity, cardiovascular complications, and hormonal imbalances.
The risk-benefit assessment of Methandrostenolone use is complex and depends on various factors, including efficacy, potential adverse effects, individual health status, and personal goals. For competitive bodybuilders and strength athletes, Methandrostenolone may present a favorable risk-benefit profile when used under appropriate medical monitoring and with conservative dosing protocols.
However, recreational users must carefully consider whether the temporary physique and performance enhancements justify potential health complications, including hepatotoxicity and cardiovascular strain. Individuals with pre-existing health conditions face substantially elevated risk profiles, making Methandrostenolone use potentially unjustifiable from a medical perspective, particularly considering the potential for liver damage.
The long-term health implications of Methandrostenolone use, classified as an anabolic steroid, remain incompletely characterized, creating uncertainty in risk quantification. The potential for serious health issues necessitates a cautious approach to its use.
In conclusion, whether Methandrostenolone is worth the risks depends on individual circumstances, including health status and performance goals. It is crucial for users to be aware of the potential side effects and to consult with healthcare professionals to make an informed decision.
Conclusion
Ultimately, the decision to use Methandrostenolone hinges on a careful consideration of its benefits and risks. Methandrostenolone, or Dianabol, is a powerful anabolic steroid that has been a staple in the bodybuilding and fitness community for decades. Its ability to promote rapid muscle growth, strength gains, and enhanced physical performance makes it an attractive option for many aspiring bodybuilders and athletes.
However, it is essential to consider the potential side effects and health risks associated with Dianabol, as well as the legal implications in your region. The compound’s mechanisms of action, including enhanced protein synthesis, increased nitrogen retention, and interaction with androgen receptors, provide substantial benefits for muscle development and strength enhancement. Nevertheless, these benefits must be weighed against significant potential health risks, including liver damage and cardiovascular complications.
Responsible use necessitates comprehensive approaches to risk mitigation, including appropriate dosage limitations, cycle duration restrictions, thorough health monitoring, implementation of protective ancillary compounds, and structured post-cycle therapy to restore physiological homeostasis. The ultimate decision regarding Methandrostenolone use requires individualized assessment of personal goals, health status, risk tolerance, and ethical considerations.
In conclusion, while Methandrostenolone can be an effective anabolic steroid for achieving rapid muscle gains and strength enhancement, its use is associated with significant potential health risks and legal considerations. Therefore, it is crucial to carefully evaluate the pros and cons before deciding to use this compound.